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Welcome to our laboratory
led by Dr. Daniel TEH

01

Wireless Optogenetics for Vision Restoration & Neuroscience Applications:

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Use of optogenetic tools to restore vision in retinal dystrophies. We are applying ultra-sensitive opsins for millisecond precision control of retinal cells in hopes of treating macular degeneration. 

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In neuroscience, our lab produces bi-stable ultrasensitive opsins for wireless optogenetics control of neural circuitry.

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02

Photodynamic Therapy (PDT)

We utilize photodynamic therapy (PDT) for targeted induction of oxidative stress in ocular and neurological tissues. These models enable us to study disease progression and test novel therapeutic interventions. â€‹In therapeutics, we apply our wireless PDT to ablate targeted tissue such as cancers.

04

Open (waiting for you)

We are constantly open to new ideas and collaboration on phototherapeutics (optogenetics & PDT). If you are keen to collaborate, please reach out to us!

03

Wireless light delivery implantable

We are the pioneer of near-infrared wireless flexible implantable for deep tissue tether free light delivery, which has application in optogenetics and PDT.

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Publications

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  1. Liu, M., Sun, Y., Teh, D. B. L., Zhang, Y., Cao, D., & Mei, Q. (2024). Nanothermometry for Cellular Temperature Monitoring and Disease Diagnostics (2/2024). Interdisciplinary Medicine, 2(2), e12096.

  2. Liu, M., Sun, Y., Teh, D. B. L., Zhang, Y., Cao, D., & Mei, Q. (2024). Nanothermometry for cellular temperature monitoring and disease diagnostics. Interdisciplinary Medicine, 2(2), e20230059.

  3. Glaviano, A., Foo, A. S. C., Lam, H. Y., Yap, K. C. H., Jacot, W., Jones, R. H., Eng, H., Nair, M. G., Makvandi, P., Geoerger, B., Kulke, M. H., Baird, R. D., Prabhu, J. S., Carbone, D., Pecoraro, C., Teh, D. B. L., Sethi, G., Cavalieri, V., Lin, K. H., Javidi-Sharifi, N. R., … Kumar, A. P. (2023). PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer. Molecular cancer, 22(1), 138. https://doi.org/10.1186/s12943-023-01827-6

  4. Kamarudin, J. B. M., Sun, B., Foo, A. S. C., Lim, X. Y., Judd, H., Tan, X., Tan, X. H., Razar, R. B. B. A., Liu, M., Zhong, J., Chua, J. J. E., Ng, C. W. Q., Goh, J. C. H., Tan, T. Z., Parikh, B. H., Su, X., Kumar, A. P., Ong, W. Y., Yamaguchi, N., Set, S. Y., … Teh, D. B. L. (2023). SIRIUS, Ultra-Scintillating Upconversion Breast Implant for Remote Orthotopic Photodynamic Therapy. ACS nano, 17(12), 11593–11606. https://doi.org/10.1021/acsnano.3c01916

  5. Ong, I., Zulkarnain, A. D. M., Lim, K. Z. Q., Teh, D. B. L., Tam, W., & Huang, Z. (2023). The global impact of COVID-19 on abortion care. Heliyon, 9(5), e16094. https://doi.org/10.1016/j.heliyon.2023.e16094

  6. Lim, X. Y., Capinpin, S. M., Bolem, N., Foo, A. S. C., Yip, W. G., Kumar, A. P., & Teh, D. B. L. (2023). Biomimetic nanotherapeutics for targeted drug delivery to glioblastoma multiforme. Bioengineering & translational medicine, 8(3), e10483. https://doi.org/10.1002/btm2.10483

  7. Farooqui, A. A., Farooqui, T., Sun, G. Y., Lin, T. N., Teh, D. B. L., & Ong, W. Y. (2023). COVID-19, Blood Lipid Changes, and Thrombosis. Biomedicines, 11(4), 1181. https://doi.org/10.3390/biomedicines11041181

  8. Lee, J. J. N., Abdul Aziz, A., Chan, S. T., Raja Abdul Sahrizan, R. S. F. B., Ooi, A. Y. Y., Teh, Y. T., Iqbal, U., Ismail, N. A., Yang, A., Yang, J., Teh, D. B. L., & Lim, L. L. (2023). Effects of mobile health interventions on health-related outcomes in older adults with type 2 diabetes: A systematic review and meta-analysis. Journal of diabetes, 15(1), 47–57. https://doi.org/10.1111/1753-0407.13346

  9. Dong, L., Teh, D. B. L., Kennedy, B. K., & Huang, Z. (2023). Unraveling female reproductive senescence to enhance healthy longevity. Cell research, 33(1), 11–29. https://doi.org/10.1038/s41422-022-00718-7

  10. Asano, T., Teh, D. B. L., & Yawo, H. (2021). Application of Optogenetics for Muscle Cells and Stem Cells. Advances in experimental medicine and biology, 1293, 359–375. https://doi.org/10.1007/978-981-15-8763-4_23

  11. Teh, D. B. L., Bansal, A., Chai, C., Toh, T. B., Tucker, R. A. J., Gammad, G. G. L., Yeo, Y., Lei, Z., Zheng, X., Yang, F., Ho, J. S., Bolem, N., Wu, B. C., Gnanasammandhan, M. K., Hooi, L., Dawe, G. S., Libedinsky, C., Ong, W. Y., Halliwell, B., Chow, E. K., … Kennedy, B. K. (2020). A Flexi-PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy. Advanced materials (Deerfield Beach, Fla.), 32(29), e2001459. https://doi.org/10.1002/adma.20200145

  12. Teh, D. B. L., Bansal, A., Chai, C., Toh, T. B., Tucker, R. A. J., Gammad, G. G. L., Yeo, Y., Lei, Z., Zheng, X., Yang, F., Ho, J. S., Bolem, N., Wu, B. C., Gnanasammandhan, M. K., Hooi, L., Dawe, G. S., Libedinsky, C., Ong, W. Y., Halliwell, B., Chow, E. K., … Kennedy, B. K. (2020). A Flexi-PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy. Advanced materials (Deerfield Beach, Fla.), 32(29), e2001459. https://doi.org/10.1002/adma.202001459

  13. Teh, D. B. L., Prasad, A., Jiang, W., Zhang, N., Wu, Y., Yang, H., Han, S., Yi, Z., Yeo, Y., Ishizuka, T., Wong, L., Thakor, N., Yawo, H., Liu, X., & All, A. (2020). Driving Neurogenesis in Neural Stem Cells with High Sensitivity Optogenetics. Neuromolecular medicine, 22(1), 139–149. https://doi.org/10.1007/s12017-019-08573-3

  14. All, A. H., Zeng, X., Teh, D. B. L., Yi, Z., Prasad, A., Ishizuka, T., Thakor, N., Hiromu, Y., & Liu, X. (2019). Expanding the Toolbox of Upconversion Nanoparticles for In Vivo Optogenetics and Neuromodulation. Advanced materials (Deerfield Beach, Fla.), 31(41), e1803474. https://doi.org/10.1002/adma.201803474

  15. Liang, L., Teh, D. B. L., Dinh, N. D., Chen, W., Chen, Q., Wu, Y., Chowdhury, S., Yamanaka, A., Sum, T. C., Chen, C. H., Thakor, N. V., All, A. H., & Liu, X. (2019). Upconversion amplification through dielectric superlensing modulation. Nature communications, 10(1), 1391. https://doi.org/10.1038/s41467-019-09345-0

  16. Blasiak, A., Guerin, T. H. M., Teh, D. B. L., Yang, I. H., Lahiri, A., & Thakor, N. V. (2019). Fibro-Neuronal Guidance on Common, 3D-Printed Textured Substrates. IEEE transactions on nanobioscience, 18(2), 226–229. https://doi.org/10.1109/TNB.2019.2905469

  17. Cai, X., Bandla, A., Chuan, C. K., Magarajah, G., De Liao, L., Teh, D. B. L., ... & Liu, B. (2019). Identifying glioblastoma margins using dual-targeted organic nanoparticles for efficient: In vivo fluorescence image-guided photothermal therapy. Materials Horizons, 6(2), 311-317.

  18. Chen, Q., Wu, J., Ou, X., Huang, B., Almutlaq, J., Zhumekenov, A. A., Guan, X., Han, S., Liang, L., Yi, Z., Li, J., Xie, X., Wang, Y., Li, Y., Fan, D., Teh, D. B. L., All, A. H., Mohammed, O. F., Bakr, O. M., Wu, T., … Liu, X. (2018). All-inorganic perovskite nanocrystal scintillators. Nature, 561(7721), 88–93. https://doi.org/10.1038/s41586-018-0451-1

  19. Teh, D. B. L., Chua, S. M., Prasad, A., Kakkos, I., Jiang, W., Yue, M., Liu, X., & All, A. H. (2018). Neuroprotective assessment of prolonged local hypothermia post contusive spinal cord injury in rodent model. The spine journal : official journal of the North American Spine Society, 18(3), 507–514. https://doi.org/10.1016/j.spinee.2017.10.066

  20. Chen, S., Weitemier, A. Z., Zeng, X., He, L., Wang, X., Tao, Y., Huang, A. J. Y., Hashimotodani, Y., Kano, M., Iwasaki, H., Parajuli, L. K., Okabe, S., Teh, D. B. L., All, A. H., Tsutsui-Kimura, I., Tanaka, K. F., Liu, X., & McHugh, T. J. (2018). Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics. Science (New York, N.Y.), 359(6376), 679–684. https://doi.org/10.1126/science.aaq1144

  21. Teh, D. B. L., Prasad, A., Jiang, W., Ariffin, M. Z., Khanna, S., Belorkar, A., Wong, L., Liu, X., & All, A. H. (2017). Transcriptome Analysis Reveals Neuroprotective aspects of Human Reactive Astrocytes induced by Interleukin 1β. Scientific reports, 7(1), 13988. https://doi.org/10.1038/s41598-017-13174-w

  22. Liu, X., Wang, Y., Li, X., Yi, Z., Deng, R., Liang, L., Xie, X., Loong, D. T. B., Song, S., Fan, D., All, A. H., Zhang, H., Huang, L., & Liu, X. (2017). Binary temporal upconversion codes of Mn2+-activated nanoparticles for multilevel anti-counterfeiting. Nature communications, 8(1), 899. https://doi.org/10.1038/s41467-017-00916-7

  23. Prasad, A., Teh, D. B. L., Blasiak, A., Chai, C., Wu, Y., Gharibani, P. M., Yang, I. H., Phan, T. T., Lim, K. L., Yang, H., Liu, X., & All, A. H. (2017). Static Magnetic Field Stimulation Enhances Oligodendrocyte Differentiation and Secretion of Neurotrophic Factors. Scientific reports, 7(1), 6743. https://doi.org/10.1038/s41598-017-06331-8

  24. Han, S., Samanta, A., Xie, X., Huang, L., Peng, J., Park, S. J., Teh, D. B. L., Choi, Y., Chang, Y. T., All, A. H., Yang, Y., Xing, B., & Liu, X. (2017). Gold and Hairpin DNA Functionalization of Upconversion Nanocrystals for Imaging and In Vivo Drug Delivery. Advanced materials (Deerfield Beach, Fla.), 29(18), 10.1002/adma.201700244. https://doi.org/10.1002/adma.201700244

  25. Peng, J., Samanta, A., Zeng, X., Han, S., Wang, L., Su, D., Loong, D. T., Kang, N. Y., Park, S. J., All, A. H., Jiang, W., Yuan, L., Liu, X., & Chang, Y. T. (2017). Real-Time In Vivo Hepatotoxicity Monitoring through Chromophore-Conjugated Photon-Upconverting Nanoprobes. Angewandte Chemie (International ed. in English), 56(15), 4165–4169. https://doi.org/10.1002/anie.201612020

  26. Prasad, A., Teh, D. B., Shah Jahan, F. R., Manivannan, J., Chua, S. M., & All, A. H. (2017). Direct Conversion Through Trans-Differentiation: Efficacy and Safety. Stem cells and development, 26(3), 154–165. https://doi.org/10.1089/scd.2016.0174

  27. Liang, L., Xie, X., Loong, D. T., All, A. H., Huang, L., & Liu, X. (2016). Designing Upconversion Nanocrystals Capable of 745 nm Sensitization and 803 nm Emission for Deep-Tissue Imaging. Chemistry (Weinheim an der Bergstrasse, Germany), 22(31), 10801–10807. https://doi.org/10.1002/chem.201602514

  28. Prasad, A., Manivannan, J., Loong, D. T., Chua, S. M., Gharibani, P. M., & All, A. H. (2016). A review of induced pluripotent stem cell, direct conversion by trans-differentiation, direct reprogramming and oligodendrocyte differentiation. Regenerative medicine, 11(2), 181–191. https://doi.org/10.2217/rme.16.5

  29. Teh, D. B., Ishizuka, T., & Yawo, H. (2014). Regulation of later neurogenic stages of adult-derived neural stem/progenitor cells by L-type Ca2+ channels. Development, growth & differentiation, 56(8), 583–594. https://doi.org/10.1111/dgd.12158

Daniel Teh's lab©2024 

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